The group (part of the RM team) is specialized in Nuclear Magnetic Resonance (NMR) and is currently actively developing an emerging nuclear hyperpolarizaiton approach called Magic Angle Spinning Dynamic Nuclear Polarizaiton (MAS-DNP). It belongs to INAC/MEM located at CEA Grenoble, is part of the PFNC, and is supported by CEA and Grenoble-Alpes University.
Our external website, which is more regularly updated with publications etc., can be found here.
Current research axes
We develop both the instrumentation and the methodology to go beyond the current sensitivity limits with the goal to significantly enlarge the scope of solid-state NMR measurements. These developments are used to reach levels of sensitivity and resolution that have never been achieved, in order to tackle highly-relevant chemical and biological questions that can't be solved by X-ray or solution-state NMR. Among the recent important contributions we made, we used MAS-DNP to probe 13C-13C proximities (~hours long experiments) at natural isotopic abundance.This is an important approach for various systems that cannot be easily isotopically enriched and for which X-ray analysis is often not suitable. We also showed that MAS-DNP could be used to answer a decades’ old problem of siloxane condensation networks (using 29Si-29Si proximities) and probe the surface structure of catalytic aluminas (using 27Al-27Al proximities and MQMAS experiments), as well as on bacterial cells. Overall, our systems of interest are rather broad and range from biomolecules and bio-materials to polymers and inorganic systems. These efforts are often combined with other expertize in EPR, DFT, and radical synthesis either through local or (inter)national collaborations.
On the instrumentation side, our effort currently involves a strong collaboration between researchers/engineers/technicians from the MEM and SBT laboratories at INAC to reach sustainable closed-loop cryogenic helium sample spinning. After several years of effort, we have successfully assembled a first-generation cryostat that is currently under testing in the DNP laboratory. The "ultra-low" temperature measurements are conducted on a prototype probe developed by Bruker Biospin.
Major milestones of our research over the last four years, besides the appended highlights can be found here.
Permanent members of the DNP group:
Maj : 17/01/2017 (1111)