Laboratoire de Chimie Inorganique et Biologique(UMR_E 3 CEA UJF)
INAC / CEA-Grenoble
17, rue des Martyrs
38 054 Grenoble cedex 9
October 2005. Habilitation à Diriger des Recherches, Université Joseph Fourier, Grenoble
Since 1st december 1997. Researcher in CEA laboratoire de Chimie Inorganique et Biologique, INAC, CEA-Grenoble
1997. post-doc., laboratoire de Chimie Inorganique et Biologique, DRFMC, CEA-Grenoble "Lanthanide ion complexation: high resolution NMR studies in solution haute"
december 1996. phD thesis at the Ecole Normale Supérieure de Lyon, title"Conception et étude de nouveaux récepteurs de cations : hémisphérands et cavitands phosphorés", in the laboratoire de Stéréochimie et des Interactions Moléculaires (ENS de Lyon, André Collet, Jean-Pierre Dutasta)
July 1992. Agrégation de Sciences Physiques option Chimie
1989-1993. Studies at the Ecole Normale Supérieure de Lyon
1987-1989. Classes préparatoires
Selective metal chelators to treat metal overload in Wilson's disease or metal intoxication
Cu(I) selective chelators were designed from binding sites found in proteins involved in copper homeostasis. Particularly efficient chelating agents were obtained by mimicking the trigonal planar geometry CuS3 of metallothionein, which are metal detoxification proteins. These chelators were transformed into prodrugs, targeted at the hepatocytes, to treat localized copper accumulation in the liver, the main organ of copper accumulation in the rare Wilson’s disease.
Gateau, C., E. Mintz and P. Delangle, Rational design of Cu and Fe chelators to treat Wilson’s disease and hemochromatosis, in Ligand Design in Medicinal Inorganic Chemistry T. Storr, Editor 2014, WILEY-BLACKWELL.
Monestier, M., P. Charbonnier, C. Gateau, M. Cuillel, F. Robert, C. Lebrun, E. Mintz, O. Renaudet and P. Delangle, ASGPR-Mediated Uptake of Multivalent Glycoconjugates for Drug Delivery in Hepatocytes. ChemBioChem, 2016, 17, p. 590-594.
Jullien, A.S., C. Gateau, C. Lebrun and P. Delangle, Mercury Complexes with Tripodal Pseudopeptides Derived from D-Penicillamine Favour a HgS3 Coordination. European Journal of Inorganic Chemistry, 2015, p. 3674-3680.
Jullien, A.S., C. Gateau, C. Lebrun and P. Delangle, Pseudo-peptides Based on Methyl Cysteine or Methionine Inspired from Mets Motifs Found in the Copper Transporter Ctr1. Inorganic Chemistry, 2015, 54, p. 2339-2344.
Jullien, A.-S., C. Gateau, I. Kieffer, D. Testemale and P. Delangle, X-Ray Absorption Spectroscopy Proves the Trigonal Planar Sulfur-Only Coordination of Cu(I) with High Affinity Tripodal Pseudopeptides. . Inorganic Chemistry, 2013, 52, p. 9954-9961.
Pujol, A.M., M. Cuillel, A.-S. Jullien, C. Lebrun, D. Cassio, E. Mintz, C. Gateau and P. Delangle, A sulfur tripod glycoconjugate releases a high affinity copper chelator in hepatocytes. Angewandte Chemie International Edition, 2012, 51, p. 7445-7448.
Pujol, A.M., M. Cuillel, O. Renaudet, C. Lebrun, P. Charbonnier, D. Cassio, C. Gateau, P. Dumy, E. Mintz and P. Delangle, Hepatocyte targeting and intracellular copper chelation by a thiol-containing glycocyclopeptide. Journal of the American Chemical Society, 2011, 133, p. 286-296.
Pujol, A.M., C. Gateau, C. Lebrun and P. Delangle, A Cysteine-Based Tripodal Chelator with a High Affinity and Selectivity for Copper(I). Journal of the American Chemical Society, 2009, 131, p. 6928-6929.
About these Cu(I) chelators and silver nanoparticles...
Veronesi, G., T. Gallon, A. Deniaud, B. Boff, C. Gateau, C. Lebrun, C. Vidaud, F. Rollin-Genetet, M. Carrière, I. Kieffer, E. Mintz, P. Delangle and I. Michaud-Soret, XAS Investigation of Silver(I) Coordination in Copper(I) Biological Binding Sites. Inorganic Chemistry, 2015, 54, p. 11688-11696.
Veronesi, G., C. Aude-Garcia, I. Kieffer, T. Gallon, P. Delangle, N. Herlin-Boime, T. Rabilloud and M. Carriere, Exposure-dependent Ag+ release from silver nanoparticles and its complexation in AgS2 sites in primary murine macrophages. Nanoscale, 2015, 7, p. 7323-7330.
Short hexapeptide sequences containing unnatural chelating amino acids have been elaborated to chelate lanthanide ions and to exploit their amazing luminescent and magnetic properties in Ln-based probes. We are currently testing their ability to interact with DNA or RNA and to detect these recognition phenomenon via the metal-centered luminescence of terbium or europium complexes or via the relaxivity of the water protons induced by the gadolinium complexes.
Niedźwiecka, A., F. Cisnetti, C. Lebrun, C. Gateau and P. Delangle, Lanthanide-binding peptides with two pendant aminodiacetate arms: impact of the sequence on chelation. Dalton Trans., 2012, 41, p. 3239-3247.
Cisnetti, F., C. Gateau, C. Lebrun and P. Delangle, Lanthanide(III) complexes with two hexapeptides incorporating unnatural chelating amino acids: secondary structure and stability. Chemistry-a European Journal, 2009, 15, p. 7456-7469.
Peptides are interesting tools to rationalise uranyl - protein interactions, which are relevant to uranium toxicity in vivo. Structured cyclic peptide scaffolds were chosen as promising candidates to coordinate uranyl thanks to four amino acid side-chains pre-oriented towards the dioxo cation equatorial plane. The binding of uranyl by a series of decapeptides has been investigated with complementary analytical and spectroscopic methods to evidence the key parameters for the formation of stable uranyl – peptide complexes.
Starck, M., N. Sisommay, F.A. Laporte, S. Oros, C. Lebrun and P. Delangle, Preorganized Peptide Scaffolds as Mimics of Phosphorylated Proteins Binding Sites with a High Affinity for Uranyl. Inorganic Chemistry, 2015, 54, p. 11557-11562.
Pardoux, R., S. Sauge-Merle, D. Lemaire, P. Delangle, L. Guilloreau, J.-M. Adriano and C. Berthomieu, Modulating Uranium Binding Affinity in Engineered Calmodulin EF-Hand Peptides: Effect of Phosphorylation. PLos ONE, 2012, 7, p. e41922.
Bonnet, C.S., P.H. Fries, S. Crouzy and P. Delangle, Outer-Sphere Investigation of MRI Relaxation Contrast Agents. Example of a Cyclodecapeptide Gadolinium Complex with Second-Sphere Water. Journal of Physical Chemistry B, 2010, 114, p. 8770-8781.
Bonnet, C.S., P.H. Fries, S. Crouzy, O. Sénèque, F. Cisnetti, D. Boturyn, P. Dumy and P. Delangle, A Gadolinium-Binding Cyclodecapeptide with a Large High-Field Relaxivity Involving Second-Sphere Water. Chemistry-a European Journal, 2009, 15, p. 7083-7093.
since 2003. Master M2 Bioorganic and Bioinorganic chemistry, Université Joseph Fourier, Grenoble (Metals, Environment, Health)
since 2002. Licence L3, Université Joseph Fourier, Grenoble (Metals and chemistry)
1993-1997. Teacher at the Ecole Normale Supérieure de Lyon