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Christelle GATEAU

Team CIBEST

INAC-SyMMES - UMR 5819 CEA CNRS UGA

CEA Grenoble

17 rue des Martyrs

38000 Grenoble

FRANCE

christelle.gateau@cea.fr

Education 

 

2016

"Habilitation" to supervise academic research in chemistry - University Grenoble Alpes - France

1999   

Doctor in Chemistry - University Louis Pasteur - Strasbourg - France

Laboratory of Synthetic Organic Chemistry (Dir. Michel FRANCK-NEUMAN)

Research activity : methodology in asymetric synthesis

1996   

Master degree - University Louis Pasteur - Strasbourg

Molecular and Supramolecular Organic Chemistry

1995  

Engineer ESIREM (ex-FIRST) – University of Burgundy

 

 

Position

 

Since 2003

Researcher CEA

RICC, SCIB/INAC/CEA-Grenoble (Dir. Pascale MALDIVI)

 then CIBEST, SyMMES/INAC/CEA-Grenbole (Dir. Pascale DELANGLE)

Research activity : design and synthesis of innovative molecules for medical imaging and metal chelation therapy

 

1999-2003

Ingénieur d’études CNRS

Laboratoire RICC, SCIB/INAC/CEA-Grenoble - 1999-2003

Research activity : Synthesis of ligands for Lanthanides/Actinides separation 

 

Research Activity

 

Design and multi-step organic synthesis of innovative molecules

Macrocyclic polyamines

- Lanthanide based imaging agents

Chemical Functionalization

- Coupling to nano-objects, DNA and Quantum-dots

- Carbohydrates/glycoconjugates for drug delivery

Peptides : non-natural amino acids and peptidic coupling

- Metal chelation therapy

- lanthanide based DNA probes

 

Students supervision 

8 PhD (1 as PhD director)

Post-doctorants and master students

 

Publications

Co-Author of 42 publications, 1 book chapter,  2 patents and 22 oral or poster contributions in national and international conference

 

Recent representative publications (2012-2017)

 

A. Conte-Daban, B. Boff, A. Candido, C. Montes Aparicio, C. Gateau, C. Lebrun , G. Cerchiaro, I. Kieffer, S. Sayen, E. Guillon, P. Delangle, C. Hureau

A trishistidine pseudopeptide with ability to remove both Cu(I) and Cu(II) from the amyloid-β peptide and to stop the associated ROS formation.

Chemistry, 2017 Accepted Article, DOI: 10.1002/chem.201703429.

 

M. Monestier, P. Charbonnier, C. Gateau, M. Cuillel, F. Robert, C. Lebrun, E. Mintz, O. Renaudet, P. Delangle

ASGPR-mediated uptake of multivalent glycoconjugates for drug delivery in hepatocytes

ChemBioChem, 2016, 17(7), pp 590-594, DOI: 10.1002/cbic.201600023

 

J. K. Molloy, C. Lincheneau, M. Moula Karimdjy, F. Agnese, L. Mattera, C. Gateau, P. Reiss, D. Imbert, M. Mazzanti

Sensitization of visible and NIR lanthanide emission by InPZnS quantum dots in biluminescent hybrids

Chem. Comm, 2016, 52, pp 4577-4580, DOI: 10.1039/C6CC01182A

 

G. Veronesi, T. Gallon, A. Deniaud, B. Boff, C. Gateau, C. Lebrun, C. Vidaud, F. Rollin-Genetet, M. Carrière, I. Kieffer, E. Mintz, P. Delangle, I. Michaud-Soret

XAS Investigation of Silver(I) Coordination in Copper(I) Biological Binding Sites

Inorg. Chem., 2015, 54 (24), pp 11688–11696, DOI: 10.1021/acs.inorgchem.5b01658

 

A-S. Jullien, C. Gateau, C. Lebrun, P. Delangle

Mercury Complexes with Tripodal Pseudopeptides Derived from D-Penicillamine Favour a HgS3 Coordination

Eur. J. Inorg. Chem., 2015, 22, pp 3674-3680, DOI: 10.1002/ejic.201500421

 

A.-S. Jullien, C. Gateau, C. Lebrun, P. Delangle

Pseudo-peptides Based on Methyl Cysteine or Methionine Inspired from Mets Motifs Found in the Copper Transporter Ctr1

Inorg. Chem., 2015, 54 (5), pp 2339–2344, DOI: 10.1021/ic502962d

 

A.-S. Jullien, C. Gateau, C. Lebrun, I. Kieffer, D. Testemale, P. Delangle

d-Penicillamine Tripodal Derivatives as Efficient Copper(I) Chelators

Inorg. Chem., 2014, 53 (10), pp 5229–5239, DOI: 10.1021/ic5004319

 

P. Delangle, C. Gateau

Design of intrahepatocyte copper(I) chelators as drug candidates for Wilson’s disease

Ann. N.Y. Acad. Sci., 2014, 1315, pp 30-36, DOI: 10.1111/nyas.12379

 

A-S. Jullien, C. Gateau, I. Kieffer, D. Testemale, P. Delangle

X-ray Absorption Spectroscopy Proves the Trigonal-Planar Sulfur-Only Coordination of Copper(I) with High-Affinity Tripodal Pseudopeptides

Inorg. Chem., 2013, 52 (17), pp 9954–9961, DOI: 10.1021/ic401206u

 

G. J. Stasiuk, S. Tamang, D. Imbert, C. Gateau, P. Reiss, P. Fries, M. Mazzanti

Optimizing the Relaxivity of Gd(III) Complexes Appended to InP/ZnS Quantum Dots by Linker Tuning

Dalton Trans., 2013, 42, pp 8197-8200, DOI: 10.1039/C3DT50774B

 

L. Ancel, C. Gateau, C., Lebrun, P. Delangle

DNA sensing by a Eu-binding peptide containing a proflavine unit

Inorg. Chem., 2013, 52, pp 552-554

 

L. Ancel, A. Niedźwiecka, C. Lebrun, C. Gateau, P. Delangle

Rational design of Lanthanide Binding Peptides Elaboration rationnelle de ligands peptidiques des ions lanthanides”

C. R. Chimie, 2013, DOI: 10.1016/j.crci.2012.12.002.

 

C. Gateau, E. Mintz, P. Delangle

Rational design of copper and iron chelators to treat Wilson’s disease and hemochromatosis

Chapter book In Ligand Design in Medicinal Inorganic Chemistry edited by Tim Storr

Wiley-Blackwell - 2013

 

A. M. Pujol, M. Cuillel, A-S. Jullien, C. Lebrun, D. Cassio, E. Mintz, C. Gateau, P. Delangle

A Sulfur Tripod Glycoconjugate Releases a High Affinity Copper Chelator in Hepatocytes

Angew. Chem. Int. Ed., 2012, 51(30), pp 7445-7448

 

G. Bozoklu, C. Gateau, D. Imbert, J. Pecaut, K. Robeyns, Y. Filinchuk, F. Memon, G. Muller, M. Mazzanti

Metal Controlled Diastereoselective Self-assembly and Circularly Polarized Luminescence of a Chiral Heptanuclear Europium Wheel

J. Am. Chem. Soc., 2012, 134(20), pp 8372-8375

 

A. M. Pujol, C. Lebrun, C. Gateau, A. Manceau, P. Delangle

Mercury-sequestering pseudopeptides with a triscysteine environment in water

Eur. J. Inorg. Chem., 2012, 24, pp 3835-3843

 

A. Niedzwiecka, F. Cisnetti, C. Lebrun, C. Gateau, P. Delangle

Lanthanide-binding peptides with two pendant aminodiacetate arms: impact of the sequence on chelation

Dalton Trans., 2012, 41, pp 3239-3247

 

A. M. Nonat, C. Gateau, P. H. Fries, L. Helm, M. Mazzanti

New bis-aqua picolinate-based gadolinium complexes as contrast agents for high-field MRI

Eur. J. Inorg. Chem. - Special Issue: Metal-Based MRI Probes (Cluster Issue) 2012, 12, pp 2049–2061

 

 

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