Feb 20, 2015
The adipose stem cells: a fountain of youth for human skin?
Contact : Walid Rachidi

Example of skin regeneration of hand skin (Dr Ali Majallal collection)

These results have just been published by researchers of the Laboratory of skin substitutes (LSC) in Lyon and CEA in Grenoble (INAC / SCIB / LAN).

 

"Our work shows that the injection of adipose stem cells increases skin regeneration. These cells have an anti-aging activity on cells from human skin, "says Walid Rachidi, professor at the UJF, which conducts his work in the laboratory Nucleic Acids (LAN-CEA Grenoble). These results were published in 2014 in the journal Stem Cell Research & Therapy. They were obtained by Elodie Metral, the PhD student whose co-Directors are Walid Rachidi and Odile Damour, director of the Laboratory for skin substitutes in Lyon and world-renowned specialist of 3D models of human skin. Their work was rewarded in November 2014 by the prize for best poster at the conference SPIM (Skin Physiology International Meeting).

It all began when Dr. Ali Mojallal, surgeon specialized in cosmetic, plastic and reconstructive surgery  at the Lyon CHU found that injection of adipose tissue appears to have a skin rejuvenating effect. Based on this clinical observation, the researchers wanted to find out which cells were responsible for the rejuvenation of the skin and if they had an anti-aging effect. They isolated stem cells from adipose tissue and injected them into a skin model reconstituted in vitro by the Laboratory of skin substitutes.

A greater proliferation of the cells and an increase in their differentiation were both noticed in the epidermis level of skin; moreover, a thickening of the papillary dermis and an increase of the extracellular matrix were observed in the dermis level of skin, which explain the effect of rejuvenation of the skin. The next step for the researchers of the LAN-CEA laboratory is such to confirm that this rejuvenated skin is both functional and able to repair UV-induced lesions. "Our work has shown that stem cells from adipose tissue contain a fountain of youth for skin cells. It is now necessary to identify which anti-aging factors they secrete in order to then make synthetic factors and move from cell therapy to drug therapy. »

 

Reference: Metral E, Santos MD, Thépot A, Rachidi W, Mojallal A, et al. (2014) Adiposederived Stem Cells Promote Skin Homeostasis and Prevent its Senescence in an In vitro Skin Model. J Stem Cell Res Ther 4: 194. doi: 10.4172/2157-7633.1000194

 

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Last update : 02/20 2015 (1093)

 

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