Uranium is a natural element widely found in the environment, due to both natural occurrence in mineral ores or in sea water and industrial applications. The production of nuclear energy uses enriched uranium in 235U for nuclear fission. Despite its ubiquitous distribution, uranium has no essential ... More »
Drug targeting is an attractive and powerful therapeutic strategy that is proposed to enhance drug efficacy and to decrease the many side-effects associated with systemic drug therapy. Indeed, it achieves specific drug accumulation in the diseased organ or cells. This strategy is exploited at INAC ... More »
Contact : Thierry Douki
Combustion of organic matter (engine exhaust, urban heating, etc.) produces some toxic and carcinogenic compounds known as Polycyclic Aromatic Hydrocarbons (PAH). After metabolization in cells they become reactive and can modify DNA. Numerous work have studied PAH as individual products. The data ... More »
To mimic the copper transport protein Ctr1, responsible for copper entrance into cells, several molecular architectures based on the symmetric scaffold, nitrilotriacetic acid (NTA) functionalized with three amino acids bearing thioether side chains were designed. These thioether derivatives form ... More »
In order to keep their genomic integrity, cells are equipped with several systems for the repair of modified bases in DNA. Scientists form INAC and IRCM (CEA/DSV-CNRS) have shown that the so-called “tandem lesions” are quite frequent and yet poorly repaired.   Several tens of ... More »


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