DNA exhibit a number of reactive sites towards electrophilic agents. Addition reactions can thus take on the various heteroatoms of the bases (N7 atoms of purines, exocyclic amino groups, O4 position of T, etc…), on C8 of purines and even on phosphates. A wide range of molecules have been identified as DNA alkylating compounds. These can either be either pollutants, industrial products, warfare agents or, more positively, antitumor drugs. In this fields, the LAN team works mostly on the quantification of the resulting DNA adducts and on the identification of the cellular processes which may modulate their formation. In that respect, metabolism of xenobiotics, detoxification mechanisms and repair are of major importance.
Last update : 10/21 2016 (1063)