This lecture outlines progress in the development of sensors and antidotes for nerve gases. Initial devices used fluorescence, and also fluorescence resonance energy transfer devices. These were modified using more powerful nucleophiles and neighboring group effects were incorporated to rapidly destroy the phosphonylated nucleophile. A series of such oximes have led to a safe compound that shows high reactivation rates for the phosphorus-conjugated butyril cholinesterase. Current research is directed at the synthesis of a prophylatic for nerve agent exposure. This work involves selective recognition of nerve agent side chains in synthetic receptors then reaction with adjacent nucleophiles. Recent developments on these fronts will be reported.
This is a joint Inac-Liten seminar