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PhD subjects

2 sujets INAC

«««

• Chemistry

Nano-sized luminescent devices based on lanthanide complexes

Contact :

Daniel IMBERT

CEA - DSM/INAC/SCIB/RICC

+33(0)438783887

Thesis supervisor :

Daniel IMBERT

CEA - DSM/INAC/SCIB/RICC

+33(0)438783887

The lanthanide-based visible and NIR luminescence emission attracts a considerable interest in the field of lighting, light emitting diodes, light converters, optical fibres for telecommunication, logic gates, barcoded materials, labels for biomedical analysis, chiral recognition or sensors. In theses fields, the creation complexes, edifices or devices based on lanthanide (III) is obtained with the association of metals and organic chromophores. Application of the supramolecular chemistry to coordination chemistry is relatively recent and of a great interest for supramolecular architectures but has lagged behind that of other systems due to the difficulty in the control of the coordination environment of the ions.

In this project the synthetic methods for the incorporation of different lanthanide ions in monometallic complexes, polymetallic assembly, multidimensional coordination polymers and multicolour platforms will be developed. The objective is to provide systems with high luminescent quantum yield and sensitization of the lanthanide ions with excitation a low energy (350-450 nm). Nano-sized materials will be developed from these assemblies. This project involves organic synthesis of new ligands and small organic molecules, the synthesis of nanoparticles and the study of their coordination chemistry lanthanide ions using different spectroscopic techniques
Nucleic Acids based-Architectures as Bio-Inspired Scaffolds for NanoTechnologies (Acronym: NatureTech)

Contact :

Didier GASPARUTTO

CEA - DSM/INAC/SCIB/LAN

04 38 78 45 48

Thesis supervisor :

Didier GASPARUTTO

CEA - DSM/INAC/SCIB/LAN

04 38 78 45 48

Nature has demonstrated an extraordinary capacity to assemble complex nanostructures with multifunctional and high reliability skills. Among all these assemblies, Nucleic Acids are biopolymers which encode the complexity of all life forms on Earth by containing the genetic blueprint, are arguably the most powerful media known for the data storage and processing. Due to the intrinsic properties of DNA, the conception of DNA-based architectures appears recently as a very exciting and promising field of research because it opens to the perspective of new devices and materials with applications in medicine, energy, electronics and photonics (1).



In the present research project we will work at the development of functionalized DNA-based architectures and bio-inspired assemblies for biological and technological applications. Firstly, the synthesis of modified DNA fragments (containing modified nucleobases, stable DNA analogs, branched structures, fluorescent dyes,...) will allow the development of new multiplexed nanobiosensors (bioprobes) or multivalent nanodrugs (inhibitors) to target enzymatic activities. Secondly, by inserting selective organic molecules into complex DNA architectures, new bio-hybrid materials and devices will be built with original intrinsic properties and potential applications in several fields of nanosciences (mainly in nanoelectronics, nanophotonics, spintronics and catalysis).



Altogether, the present research project constitutes a cross-disciplinary program with a strong trainer character for the applying candidate and important synergies between several collaborative laboratories.



(1) (a) Zhang F. et al. ?Structural DNA nanotechnology: state of the art and future perspective? J. Am. Chem. Soc. 136, 11198 (2014); (b) ?Nucleic Acid Nanotechnology?, Accounts in Chemical Research, 47, 1643 (2014) - Guest Editors N. C. Seeman, C. Mao & H. Yan.

 

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