Dernière mise à jour : 01-07-2016

3 sujets INAC

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• Chemistry

3 réponse(s)

Making use of the unprecedented sensitivity of DNP-enhanced solid-state NMR: structure-function studies of materials for a greener future

SL-DSM-16-0562

Research field : Chemistry

Location :

Service de Chimie Inorganique et Biologique (SCIB)

Laboratoire de Résonance Magnétique (RM)

Grenoble

Contact :

Daniel LEE

Gaël DE PAEPE

Starting date : 01-10-2016

Contact :

Daniel LEE

CEA - DSM/INAC/SCIB/RM

0438786584

Thesis supervisor :

Gaël DE PAEPE

CEA - DSM/INAC/SCIB/LRM

04 38 78 65 70

More : http://inac.cea.fr/Pisp/daniel.lee/

More : http://inac.cea.fr/en/Phocea/Vie_des_labos/Ast/ast_visu.php?id_ast=1111

INAC (Institute for Nanoscience and Cryogenics, CEA Grenoble) has a PhD opening for a physical chemist. This position will deal with the development and application of a new and emerging technique: high magnetic field MAS-DNP (Magic Angle Spinning Dynamic Nuclear Polarization). This powerful tool is used to hyperpolarize nuclei such that high-sensitivity and high-resolution solid-state NMR (Nuclear Magnetic Resonance) spectra can be obtained and used to extract important structural information at the atomic-scale, such as surface functionalization and internuclear distances (see ref. 1), as well as crystallographic data (see ref. 2).

Since the potential of this technique is beginning to be realized (see ref. 3), the aim of this PhD will be to further develop the methodology to apply it to study materials of significant importance for the future of “greener” energy, which could not have been otherwise investigated in such a manner. The studied materials will arise from diverse but related fields including heterogeneous catalysis, fuel cells, photovoltaics, and nuclear wastes.

This PhD will take place in the highly dynamical environment of the MINATEC campus (CEA Grenoble) and more specifically in the nanocharacterization platform (PFNC) where the DNP group, in collaboration with Bruker Biospin (world leader in DNP and NMR instrumentation), is currently pushing the development and use of MAS-DNP beyond its current state-of-the-art. The group is working with the first high-field MAS-DNP system installed in France (since September 2011) and has successfully conducted instrumental and methodological developments over the last three years (a selection of which are given in the references).

Overall, we aim to demonstrate that with the several orders of magnitude of sensitivity gain achievable with MAS-DNP, solid-state NMR has the potential to address crucial problems for systems where other well-established spectroscopies (X-ray analysis, solution-state NMR, etc.) cannot be applied successfully.

This PhD will take place involving strong partnerships with different academic laboratories within CEA and INAC (SCIB and SPRAM) as well as CEA/ICSM and industrial partners (such as Bruker Biospin).
N-type semiconducting polymers for applications in organic photovoltaic and thermoelectric devices

Contact :

Renaud DEMADRILLE

CEA - DSM/INAC/SPrAM/LEMOH

04 38 78 44 84

Thesis supervisor :

Renaud DEMADRILLE

CEA - DSM/INAC/SPrAM/LEMOH

04 38 78 44 84

More : http://inac.cea.fr/Pisp/57/renaud.demadrille.html

More : http://www.spram-solar.fr/

Organic bulk-heterojunction solar cells are based on a mixture of semiconductors, in general a p-type pi-conjugated polymer (electron donor) and an n-type fullerene derivative (electron acceptor) which form two interpenetrating networks. The photoactive layer is placed between two electrodes with at least one that is transparent to allow absorption of light. A large number of studies have been reported over the last 15 years with the goal to improve the properties of p-type polymers. Following this strategy the power conversion efficiencies of polymer solar cells have reached 10%. However, to improve further these performances, the development of n-type semiconducting polymers to replace the fullerenes seems promising.

N-type polymer materials could also be very useful in the development of thermoelectric generators. Indeed it was recently discovered that conjugated polymers behave as thermoelectric materials, and they can convert heat into electricity. In this project, new n-type polymers will be developed and their structural and optoelectronic properties will be fully characterized by multiple techniques available in the laboratory. The materials' performance will be evaluated in photovoltaic and thermoelectric devices fabricated in the laboratory.
Innovative therapeutic strategies for Wilson disease

Contact :

Christelle GATEAU

CEA - DSM/INAC/SCIB/RICC

0438786041

Thesis supervisor :

Christelle GATEAU

CEA - DSM/INAC/SCIB/RICC

0438786041

More : http://inac.cea.fr/Pisp/christelle.gateau/

More : http://inac.cea.fr/Phocea/Vie_des_labos/Ast/ast_groupe.php?id_groupe=545

Wilson's disease is one of the major genetic disorders of copper metabolism in humans and results in an accumulation of copper in the liver and the brain. In this project, we propose innovative therapeutic strategies based on the delivery of an effective copper chelator specifically in the liver or in the brain.

Various molecular architectures and nanoparticles combining copper chelators to specific drug delivery units will be designed. The capacity of these systems to enter the targeted cells and their ability to deliver an effective copper chelator will be evaluated in biological models.

This multidisciplinary project involves multi-step syntheses of various molecular architectures, formulation of lipid nanoparticles and their advanced characterization, as well as the evaluation of these innovative delivery systems in biological models.

The PhD candidate should have a solid knowledge and experience in organic chemistry. An additional experience in nanoparticle formulation and/or cellular assays would be appreciated. The candidate should be motivated and curious.

 

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