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Yanxia HOU-BROUTIN

Groupe Chimie pour la Reconnaissance et l’Etude d’Assemblages Biologiques

SyMMES UMR 5819 (CEA, CNRS, UGA), INAC, CEA-Grenoble

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Function

Researcher at CNRS (Centre National pour la Recherche Scientifique) since October 2008

Research interests

Biosensors/Biochips

Electronic noses/tongues

Surface chemistry

Nanobiotechnologies

CV

Since Oct 2008: Researcher at CNRS

Jan 2007 - Sep 2008: Postdoc, CEA-Leti/DTBS (France)

Jan 2006 - Dec 2006: Postdoc, University of California San Francisco, Touro University (USA)

Sep 2002 - Nov 2005: PhD in Analytical Chemistry, Ecole Centrale de Lyon (France)

Sep 1999 - July 2002: Master in Chemistry, Central China Normal University (China)

Funding

H2020-FETOPEN (Project Abiomater 11/2015-10/2018), EURONANMMED II (Project Nanoviber 01/2017-12/2019), ANR (Project Nano-SHARK 11/2011-10/2015), FUI (Project WISE 07/2016-06/2019), Fondation Nanosciences ( PhD program 12/2017-11/2020, Chair of Industrial Excellence Program 2017), CEA DRF Impulsion (Project Hybridimer 2017), Labex Arcane AAP Valo (06/2015-05/2016), Programme Transversal Nanosciences CEA (Project NanoGAGs2Gre 10/2013-09/2015), Labex Lanef PhD program (10/2012-09/2015)

Scientific publications

[26] Mode of PEG coverage on carbon nanotubes affects binding of innate immune protein C1q

         A. Belime, E. Gravel, S. Brenet, S. Ancelet, Y. Hou, Nicole Thielens, Eric Doris, Wai Li Ling*

         The Journal of Physical Chemistry, 2017 (DOI: 10.1021/acs.jpcb.7b06596).

[25] Fabrication of monodisperse magnetic nanoparticles released in solution using a block copolymer template

        M. Morcrette, G. Ortiz, S. Tallegas, H. Joisten, R. Tiron, T. Baron, Y. Hou, S. Lequien, A. Bsiesy, B. Dieny*

        Journal of Physics D: Applied Physics, 2017 (50) 295001.

[24] A Versatile Electronic Tongue Based on Surface Plasmon Resonance Imaging and Cross-Reactive Sensor Arrays - A Mini-review

        L. A. Garçon, M. Genua, Y. J. Hou, A. Buhot, R. Calemczuk, T. Livache, M. Billon, D. Bonnaffé, H. Lortat-Jacob, Y. Hou*

        Sensors, 2017, 17, 1046 (DOI:10.3390/s17051046).

[23]  Remotely Actuated Magnetic Nanotweezers for Applications in Biology and Nanomedicine

        C. Iss, G. Ortiz, A. Truong, Y. Hou, T. Livache, R. Calemczuk, P. Sabon, E. Gautier, S. Auffret, H. Joisten, and B. Dieny*

        Scientific Reports 7, 2017, Article number: 451, (DOI:10.1038/s41598-017-00537-6)

[22] Triggering the apoptosis of targeted human renal cancer cells by the vibration of anisotropic magnetic particles attached to the cell membrane

       S. Leulmi, X. Chauchet, M. Morcrette, G. Ortiz, H. Joisten, P. Sabon, T. Livache, Y. Hou, M. Carrière, S. Lequiena, B. Dieny*

       Nanoscale, 2015, 7, 15904–15914.

[21] Integrating Multi-Functionalities into Non-Spherical Microparticles Fabricated by Top-Down Approach

        M. Genua, N. Reinhardt, J. Faure-Vincent, R. Calemczuk, T. Livache, Y. Hou*

        Science of Advanced Materials, 2015, 7, 1779-1784.

[20] Complex Mixtures Analysis by Landscape Imaging Based Electronic Tongue

M. Genua, L. A. Garçon, V. Mounier, H. Wehry, A. Buhot, M. Billon, R. Calemczuk, D. Bonnaffé, Y. Hou, T. Livache

Talanta, 2014, 130, 49-54.

[19] Electronic tongue generating continuous recognition patterns for protein analysis

Y. Hou, M. Genua, L. A. Garçon, A. Buhot, R. Calemczuk, D. Bonnaffé, H. Lortat-Jacob, T. Livache

Journal of Visualized Experiments, 2014, e51901.

[18] Landscapes of taste by a novel electronic tongue for the analysis of complex mixtures

L. A. Garçon, Y. J. Hou, M. Genua, A. Buhot, R. Calemczuk, D. Bonnaffé, Y. Hou,  T. Livache

Sensor Letters, 2014, 12,  1-6.

[17] Continuous evolution profiles for electronic tongue based analysis

Y. Hou, M. Genua, D. Tada Batista, R. Calemczuk, A. Buhot, P. Fornarelli, J. Koubachi, D. Bonnaffé, E. Saesen, C. Laguri, H. Lortat-Jacob, T. Livache

Angewandte Chemie International Edition, 2012,  51, 10394-10398.

[16] An artificial ion channel biosensor in human immunodeficiency virus gp41 drug sensing

Y. Hou, M. Gochin

Anal. Chem., 2008, 80, 5924-5929.

[15] Nanobiosensors based on individual olfactory receptors

V. Akimov, E. Alfinito, J. Bausells, I. Benilova, I. C. Paramo,A.  Errachid, G. Ferrari, L. Fumagalli, G. Gomila, J. Grosclaude, Y. Hou, N. Jaffrezic-Renault, C. Martelet, E. Pajot-Augy, C. Pennetta, M.A. Persuy, M. Pla-Roca, L. Reggiani, S. Rodriguez-Segui, O. Ruiz, R. Salesse, J. Samitier, M. Sampietro, A. P. Soldatkin, J. Vidic, G. Villanueva

Analog Integr Circ Sig Process, 2008, 57, 197–203.

[14] A novel detection strategy for odorant molecules based on a controlled bioengineering of rat olfactory receptor 17 (OR17)

Y. Hou, N. Jaffrezic-Renault, C. Martelet, A. Zhang, J. Minic, T. Gorojankina, M. A. Persuy, E.  Pajot-Augy, R. Salesse, V. Akimov, L. Reggiani, C. Pennetta, E. Alfinito, O. Ruiz, G. Gomila, J. Samitier, A. Errachid

Biosensors and Bioelectronics, 2007, 22, 1550-1555.

[13] Gold surface functionalization and patterning  for specific immobilization of olfactory receptor carried by nanosomes

J. Vidic, M. Pla-Roca, J. Grosclaude, M. A. Persuy, R. Monnerie, D. Caballero, A. Errachid, Y. Hou, N. Jaffrezic-Renault, R. Salesse, E. Pajot-Augy,  J. Samitier

Analytical Chemistry, 2007, 79, 3280-3290.

[12] Immobilization of Rhodopsin on a self-assembled multilayer and its specific detection by electrochemical impedance spectroscopy

Y. Hou, S. Helali, A. Zhang, N. Jaffrezic-Renault, C. Martelet, J. Minic, T. Gorojankina, M. A. Persuy, E.  Pajot-Augy, R. Salesse, F. Bessueille, J. Samitier, A. Errachid, V. Akinov, L. Reggiani, C. Pennetta, E. Alfinito

Biosensors and Bioelectronics, 2006,21, 1393-1402.

[11] Detection of olfactory receptor I7 self assembled multilayer formation and immobilization using Quartz Crystal Microbalance

S. Rodríguez Seguí, M. Pla, J. Minic, E. Pajot-Augy, R. Salesse, Y. Hou, N. Jaffrezic-Renault, C. A. Mills, J. Samitier, A. Errachid

Analytical Letters, 2006, 39, 1735-1745.

[10] Advances in the production, immobilization, and electrical characterization of olfactory receptors for olfactory nanobiosensor development

G. Gomila, I. Casuso, A. Errachid, O. Ruiz, E. Pajot, J. Minic, T. Gorojankina, M. A. Persuy, J. Aioun, R. Salesse, J. Bausells, G. Villanueva, G. Rius, Y. Hou, N. Jaffrezic, C. Pennetta, E. Alfinito, V. Akimov, L. Reggiani, G. Ferrari, L. Fumagalli, M. Sampietro, J. Samitier

Sensors and Actuators B, 2006,116, 66-71.

[9] Study of Langmuir and Langmuir-Blodgett films of odorant-binding protein/amphiphile for odorant biosensor

Y. Hou,  N. Jaffrezic-Renault, C. Martelet, C. Tlili, A. Zhang, J. C. Pernollet, L. Briand, G. Gomila, A. Errachid, J. Samitier,  L. Salvagnac , B. Torbiéro, P. Temple-Boyer

Langmuir, 2005, 21, 4058-4065.

[8] Elaboration of odorant biosensors based on Langmuir-Blodgett technique

Y. Hou, N. Jaffrezic-Renault , C. Martelet, C. Tlili, A. Zhang

Journal of Advanced Science2005,17, 49-54.

[7] Immobilization of native membrane-bound rhodopsin on biosensor surfaces

J. Minic, J. Grosclaude, J. Aioun, M. A. Persuy, T. Gorojankina, R. Salesse, E. Pajot-Augy, S. Helali, Y. Hou, N. Jaffrezic-Renault, F. Bessueille, A. Errachid, G. Gomila, O. Ruiz, J. Samitier

Biochimica et Biophysica Acta (BBA), 2005, 1724, 324-332.

[6] Quantitative determination of Zinc in milkvetch by anodic stripping voltammetry with bismuth film electrodes

Z. Guo, F. Feng, Y. Hou, N. Jaffrezic-Renault

Talanta, 2005, 65, 1052-1055.

[5] Impedancemetric probing of mixed amphiphile-antibody films transferred onto silver electrodes

T. Chaker, Y. Hou, H. Korri-Youssfi, L. Ponsonnet, C. Martelet, A. Errachid, N. Jaffrezic-Renault

Sensor letters, 2005, 2,1-6.

[4] Study of mixed Langmuir-Blodgett films of immunoglobulin G/amphiphile and their application for immunosensor engineering

Y. Hou, C. Tlili, N. Jaffrezic-Renault, A. Zhang, C. Martelet, L. Ponsonnet, A. Errachid, J. Samitier, J. Bausells

Biosensors and Bioelectronics, 2004,20, 1126-1133.

[3] Study of pure urease Langmuir-Blodgett film and application for biosensor development

Y. Hou, N. Jaffrezic-Renault, A. Zhang, J. Wan, A. Errachid, J. M. Chovelon

Sensors and Actuators B, 2002, 86, 143-149.
 

[2] Mixed urease/amphiphile LB films and their application for biosensor development

A. Zhang, Y. Hou, N. Jaffrezic-Renault, J. Wan, A. Soldatkin, J. M. Chovelon

Bioelectrochemistry, 2002, 56, 157-158.

[1] Optimization of the mixed urease/amphiphile Langmuir-Blodgett film and its application for biosensor development

A. Zhang, N. Jaffrezic-Renault, J. Wan, Y. Hou, J. M. Chovelon

Material Science and Engineering C, 2002,21, 91-96.

Patents

[4] Composés chimiques mis en œuvre comme surfaces de référence pour déterminer le bruit d'un capteur multiplexé de type nez électronique et d'en diminuer la dérive

        Y. Hou-Broutin, S. Brenet, T. Livache, C. Herrier, T. Rousselle, FR1758547, 2017. 

[3] Procédé de calibration d'un nez électronique

        T. Livache, F.X. Gallat, Y. Hou-Broutin, C. Herrier, T. Rousselle, FR1751751, 2017.

[2] Capteurs de nez ou de langue électronique

T. Livache, A. Buhot, D. Bonnaffé, Y. Hou-Broutin, 2013, WO2013/124810.

[1] Device for detecting gases and/or volatile organic compounds (VOC) 

Delapierre Guillaume, Hou-Broutin Yanxia, Mccaig Heather, Myers Edward, Roukes Michael L., 2011, WO201136565.

Book Chapters

[3] Nanobiosensors based on individual olfactory receptors

V. Akimov, E. Alfinito, J. Bausells, I. Benilova, I. C. Paramo, A. Errachid, G. Ferrari, L. Fumagalli, G. Gomila, J. Grosclaude, Y. Hou, N. Jaffrezic-Renault, C. Martelet, E. Pajot-Augy, C. Pennetta, M. A. Persuy, M. Pla-Roca, L. Reggiani, S. Rodriguez-Segui, O. Ruiz, R. Salesse, J. Samitier, M. Sampietro, A. P. Soldatkin, J. Vidic, G. Villanueva

Analog Integrated Circuits and Signal Processing, Springer Netherlands, 2008, Vol 57, 197-203.

[2] Nanostructuration and nanoimaging of biomolecules for biosensors

C. Martelet, N. Jaffrezic-Renault, Y. Hou, A. Errachid, F. Bessueille

Applied Scanning Probe Methods VII, Springer-Verlag, Heidelberg, 2007, Vol 6, 225-257.

[1] Towards the realization of noanobiosensors based on G-protein coupled receptors

C. Pennetta, V. Akimov, E. Alfinito, L. Reggiani, T. Gorojankina, J. Minic, E. Pajot-Augy, M. A. Persuy and R. Salesse I. Casuso, A. Errachid, G. Gomila, O. Ruiz, J. Samitier, Y. Hou,  N. Jaffrezic, G. Ferrari, L. Fumagalli, M. Sampietro

Nanodevices for the  Life sciences, Wiley, 2006, Vol 7, 217-241.

 

Highlights

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Le Journal du Dimanche 04/07/2017

 

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Lettre de CNRS Innovation, 20/10/2016 (http://www.cnrs.fr/lettre-innovation/lettre.php?numero=25)

 

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CNRS International magazine 2013, N° 28, page 11 (http://www.cnrs.fr/fr/pdf/cim/CIM28.pdf)
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Communiqués de press de CNRS-Paris, 18/10/2012 
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MinaNews of Minatec, 2012, N°22
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Communiqués de press CNRS-Alpes, 19/10/2012
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Press release by Angew. Chem. Int. Ed. (http://onlinelibrary.wiley.com/journal/10.1002/%28ISSN%291521-3773/homepage/press/201237press.html)
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Communiqués de presse CEA, 18/10/2017
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Communication CEA-DSM, 24/10/2012
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Newsletter of Giant, 06/11/2012

 

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